Myocardial infarction is resulted from imbalance between the coronary oxygen supply and demand to myocardium of\r\nheart. Ischemic heart diseases are leading causes of mortality in developed and developing countries. It is well recognised that\r\nformation of reactive oxygen species such as superoxide anion and hydroxyl radical and other species in the ischemic zone can\r\ndamage the cell membrane lipids, proteins, carbohydrates and DNA and result in cell dysfunction and apoptosis. Traditionally\r\nclove is used as culminate in diet obtained from clover bud of Eugenia caryophyllus. Clove oil contain eugenol, is a good\r\nantioxidant. The present study was aimed to study the effect of clove oil on serum marker enzymes, lipid peroxidation and\r\nendogenous antioxidants in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO\r\n(100 mg/kg, S.C) for 2 days at an interval of 24 h caused a significant (P<0.001) elevation of serum marker enzymes, lipid\r\nperoxidation and whereas there was a significant (P<0.001) decrease in endogenous antioxidants. Administration of clove oil\r\n(719.5/kg/oral) for 15 days and challenged with ISO on the day 14th and 15th showed a significant (P<0.001) decrease in serum\r\nmarker enzymes, lipid peroxidation and a significant (P<0.001) increase in the endogenous antioxidants. These findings indicate\r\nthat clove oil has cardio protective effect against ISO induced myocardial infarction in rats.
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